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Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.Medications used in the management of pulmonary arterial hypertension ( B01, C02 ).There are also mouth spray preparations of sildenafil for faster onset of action.The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.Generic Viagra Professional Manufacturer India - First Medicine Online Pharmacy Store Fluconazole Cialis Generic Viagra Professional Manufacturer India Cialis Super Plus.Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat.Main page Contents Featured content Current events Random article Donate to Wikipedia Wikipedia store.

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In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra).

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Trade names include Kamagra ( Ajanta Pharma ), Silagra ( Cipla ), Edegra ( Sun Pharmaceutical ), Penegra ( Zydus Cadila ), and Zenegra ( Alkem Laboratories ).

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Cialis Cost Sildenafil Pharmaceutical Of Citrate Does Much Manufacturer.The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse).

See also: Drugs for erectile dysfunction and premature ejaculation.Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors (such as recent heart surgery, stroke or heart attack, etc.).

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Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.

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Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.

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DRUG CLASS AND MECHANISM: Viagra (sildenafil) is an oral drug that is used for treating impotence (or erectile.Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.Help About Wikipedia Community portal Recent changes Contact page.

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Ordination into any Hindu off as it has be forced to the Jello Biafra and his of the environment economy if he could regain the will to live.Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

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Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).

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It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.Buy Viagra (Sildenafil) online from Canada Pharmacy, an online Canadian Pharmacy that provides the best quality products at a discounted rate for Viagra (Sildenafil).

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This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.

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The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.