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Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.

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Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.

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Viagra is usually taken regarding 30-45 mins before sexual task and the results last for 4 hours on the average.

Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE 5 ), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.Nearly five years ago, a diamond-shaped blue pill called Viagra was introduced to an eager public.Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments.

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Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.

Drugs for erectile dysfunction ( G04BE ) and premature ejaculation.Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).

The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.Main page Contents Featured content Current events Random article Donate to Wikipedia Wikipedia store.The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse).In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra).

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When autoplay is enabled, a suggested video will automatically play next.By using this site, you agree to the Terms of Use and Privacy Policy.Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).Viagra at The Periodic Table of Videos (University of Nottingham).The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.What links here Related changes Upload file Special pages Permanent link Page information Wikidata item Cite this page.In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester, England.

Erectile Function And Dysfunction Part 5 - Viagra - Management Of E.D.Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

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View images of Viagra and identify pills by imprint code, shape and color with the Drugs.com Pill Identifier.Caution is advised in those who have cardiovascular disease.

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There are also mouth spray preparations of sildenafil for faster onset of action.

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Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.Common side effects include headaches and heartburn, as well as flushed skin.