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Help About Wikipedia Community portal Recent changes Contact page.Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).Viagra or Generic Viagra is often the first treatment tried for erectile dysfunction in men and pulmonary arterial hypertension.Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.

Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate.

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Common side effects include headaches and heartburn, as well as flushed skin.Bank with First Federal Bank in OH, MI and IN and enjoy great personal and business banking solutions.

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Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection.

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This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.

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Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat.Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.

Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors (such as recent heart surgery, stroke or heart attack, etc.).In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra).Medications used in the management of pulmonary arterial hypertension ( B01, C02 ).Read the informative research article by Jim Edwards from BNET, to see what will happen with Authentic Viagra.

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The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.Main page Contents Featured content Current events Random article Donate to Wikipedia Wikipedia store.

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Caution is advised in those who have cardiovascular disease.Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.

Trade names include Kamagra ( Ajanta Pharma ), Silagra ( Cipla ), Edegra ( Sun Pharmaceutical ), Penegra ( Zydus Cadila ), and Zenegra ( Alkem Laboratories ).Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).By using this site, you agree to the Terms of Use and Privacy Policy.See also: Drugs for erectile dysfunction and premature ejaculation.

The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse).What links here Related changes Upload file Special pages Permanent link Page information Wikidata item Cite this page.

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