This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester, England.
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Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.
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The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.
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