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This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester, England.

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Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors (such as recent heart surgery, stroke or heart attack, etc.).Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE 5 ), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.Sildenafil citrate 100mg (Generic Viagra) improves male performance.Medications used in the management of pulmonary arterial hypertension ( B01, C02 ).Drugs for erectile dysfunction ( G04BE ) and premature ejaculation.

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Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.

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Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.Includes common and rare side effects information for consumers and healthcare professionals.

The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.

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All medicines have side effects. Viagra tablets contain sildenafil (as citrate) equivalent to 25 mg, 50 mg or 100 mg sildenafil.Edegra 100 mg Reviews: Most of Customers are Satisfied. Effect of Edegra 100mg remains in the body for up.

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Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.

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