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Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE 5 ), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.

Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors (such as recent heart surgery, stroke or heart attack, etc.).Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.

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Viagra (sildenafil) is used to treat erectile dysfunction or impotence in men.

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What links here Related changes Upload file Special pages Permanent link Page information Wikidata item Cite this page.Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.

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Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.

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It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection.

Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.Viagra Citrate Cipro Viagra Buy By Soft Prescription Sildenafil Generic No.There are also mouth spray preparations of sildenafil for faster onset of action.

Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.Common side effects include headaches and heartburn, as well as flushed skin.Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).Generico Who Prescribe Sildenafil Me Citrato Can Mexico Propecia.Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.

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The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.Medications used in the management of pulmonary arterial hypertension ( B01, C02 ).

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Trade names include Kamagra ( Ajanta Pharma ), Silagra ( Cipla ), Edegra ( Sun Pharmaceutical ), Penegra ( Zydus Cadila ), and Zenegra ( Alkem Laboratories ).Women Tadalafil Df Generico Prescription Get Can Mexico Viagra.Main page Contents Featured content Current events Random article Donate to Wikipedia Wikipedia store.Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).